Project: Autism Centers of Excellence: Infant Brain-Imaging Study


A longitudinal study with image processing and analysis of MRI/DTI of infants at high risk for autism at 6, 12, and 24 months of age.

Utah is the Imaging Core on this project: the core is responsible for development, validation and application of image segmentation and analysis to pediatric MRI/DTI of over 400 subjects acquired at 4 different imaging sites.


This project is part of the Carolina Institute for Developmental Disabilities. As part of the ACE network, this project is a collaborative effort by investigators at four clinical sites (University of North Carolina, University of Washington, Washington University, and Yale University) and one data-coordinating center at the Montreal Neurological Institute to conduct a longitudinal MRI/DTI and behavioral study of infants at high risk for autism (i.e., siblings of autistic individuals) at 6, 12, and 24 months of age.

Guido Gerig acts as joint PI of the Neuroimaging Core of the ACE network. The primary objective of the Core is to serve the whole ACE Project with image-analysis technology to study brain MRI/DTI of autistic children from 6 months to 2 years old. Image data will be collected with the Montreal DCC and then transferred to UNC and Utah for processing. The Core provides state-of-the-art processing technology for MR imaging of infants, and it uses validated image analysis to target patient needs. This group is particularly important because of the sensitivity and need to provide brain imaging and analysis at this critical age. The processing of data is shared between North Carolina and Utah laboratories, using new capabilities of networked computing infrastructure and secure transfer systems.






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  • ACE RO1 HD 055741